Comparison of Intraoperative Haemodynamic Parameters And Cost Effectiveness Between Sevoflurane (Inhaltional) Anaesthesia And Propofol (Tiva) Based Anaesthesia

Background: Intravenous Propofol as Total Intravenous Anaesthesia (TIVA) is being widely used for the induction and maintenance of anaesthesia. Sevoflurane is a relatively newer anaesthetic agent which is expensive, but has the advantage of rapid induction and recovery characteristics. Materials and Methods: Sixty patients ASA Grade I and II aged 18-65 yrs were randomly divided into two groups. Group A received Sevoflurane inhalational induction via a vital capacity rapid inhalational induction (VCRII) technique using 8% Sevoflurane from a closed circuit primed for 1 minute. Maintenance was done with 1.5-2% Sevoflurane. Group B patients were induced with Propofol i.v 2-2.5mg/kg. Intraoperative maintenance was done with multistep Propofol infusion (8mg/kg/hr -3mg/kg/hr) via infusion pump. Results: Induction time was faster in Sevoflurane group as compared to Propofol group (p<0.001), which was highly significant. The intraoperative haemodynamics were comparable between the two groups with no statistically significant difference. The recovery profile was significantly (p<0.001) better with Sevoflurane group as regards the spontaneous eye opening, verbal communication and mental orientation. Although the total volume of each agent used was almost similar in both groups, but the cost incurred in Sevoflurane anaesthesia is still higher than the Propofol based anaesthesia. Conclusion: Sevoflurane is a good alternative for Propofol as an induction and maintenance agent with better recovery profile, but has cost limitations.